Although the underlying disease mechanism of CRB1 retinopathy remains unclear, a recent study using the oko meduzy (crb2am289) zebrafish model and human retinal organoids derived from LCA8 patient-specific induced pluripotent stem cells (hiPSCs) showed abnormal regulation in transcriptional and cell cycle pathways, and epigenetic pathways with global correlation between the transcriptome and methylation status. This evidence concerns the gene CRB1 and retinal disorder.