BRAF and melanoma: Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors in V-RAF murine sarcoma viral oncogene homolog B (B-RAF) or neuroblastoma RAS viral (V-Ras) oncogene homolog (N-RAS) mutant melanomas was mediated by PGC-1α overexpression and could be reversed by mTORC1/2 inhibition [100].