The picomolar IC50 also agrees with picomolar IC50s for simufilam’s inhibition of the Aβ42–α7nAChR interaction, tau hyperphosphorylation, and FLNA–α7nAChR/TLR4 interactions calculated for a range of concentrations in postmortem brain [10] and also shown in AD mouse models or AD patient lymphocytes [8,9,10]. Here, MAPT is linked to Alzheimer disease.