In addition, in agreement with these data, a study in an in vitro model of AD has suggested that the NCX3-mediated replenishment of the endoplasmic reticulum Ca2+ stores is a pivotal mechanism acting in neuronal homeostasis and supporting neuronal survival under pathological conditions, such as those triggered by Aβ1–42 oligomers [34]. The gene discussed is SLC8A3; the disease is Alzheimer disease.