In a study performed by Luczak et al. on 46 patients with pSS and 30 control subjects without known cardiovascular disease revealed that the FMD was correlated with disease activity (p = 0.02), focus score (p = 0.04), anti SS-A-antibody titer (p = 0.03), and pulmonary involvement (p = 0.001) [40]. This evidence concerns the gene CALR and cardiovascular disorder.