Weiner et al. reported a significant inverse correlation between IL-6 levels and FMD (r = −0.042; p = 0.02) after adjustment for age, gender, race/ethnicity, education, income, low-density lipoprotein, diabetes, glucose, hypertension status and treatment, waist circumference, triglycerides, baseline brachial diameter, recent infection, and the use of medications that may alter inflammation [47]. This evidence concerns the gene IL6 and hypertensive disorder.