POLD4 and central nervous system cancer: As expected, the high-POLD4 group showed significantly higher expression of PCNA (Figure 14C), CD163 (Figure 14D), CD206 (Figure 14E), and PDL1 (Figure 14F) compared to the low-POLD4 group, further confirming the correlation between POLD4 and glioma cell proliferation and the immunosuppressive microenvironment.