The pathways exhibiting the highest correlation with POLD4 expression in GBM include Inflammatory Response, Complement, Allograft Rejection, Coagulation, IL6/JAK/STAT3 Signaling, IL2/STAT5 Signaling, Apoptosis, and Reactive Oxygen Species pathway (Figure S7). The gene discussed is POLD4; the disease is glioblastoma.