HK2 and prostate cancer: Indeed, the Warburg effect is critically involved in prostate cancer progression [11], with Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) loss [12] and glycolysis-associated proteins such as pyruvate kinase-M2 (PKM2), glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and lactate dehydrogenase (LDH) [13,14].