According to RNA sequencing data from the TCGA and GTEx databases using GEPIA, though the significant difference in SIRT 1 was not accepted between cancer patients (n = 492) and a normal group (n = 152) (Figure 4a), a lower SIRT1 expression was associated with an improved overall survival in prostate cancer patients (Figure 4b). This evidence concerns the gene SIRT1 and Familial prostate cancer.