IGF1 and heart disorder: Numerous studies have examined the connection between various GHR genotypes and several comorbidities linked to patients with active acromegaly, such as hypertension, obesity, T2DM, colonic polyps, heart disease, obstructive sleep apnea syndrome, vertebral fractures (VF), and heart disease, in addition to the effect of each genotype on GH, IGF-I, and BMI levels [44,113,118,119,120,121,122].