TG and Menkes disease: The pathway analysis results from the predicted target genes of hsa-miR-2277-3p confirmed the involvement of multiple processes in the pathophysiology of MD, including dopaminergic neurogenesis, thyroxine (thyroid hormone) production, oxidative stress, oxidative stress response, tryptic production, tryptophan metabolism, nitric oxide-cyclic guanosine monophosphate-protein kinase G pathway-mediated neuroprotection, and methylation pathways (Table 5).