Zhao et al. revealed the m6A changes in different brain regions/cells of AD patients, as well as the reduced expression of the writers (METTL3, METTL14, and WTAP), eraser (FTO), and reader (YTHDF1), and also revealed abnormality nuclear localization of METTL3/14 [145]. The gene discussed is YTHDF1; the disease is Alzheimer disease.