In the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, m6A-related proteins exhibited differential expression levels, such as ALKBH5 and YTHDF1, suggesting the potential role of m6A modification in PD pathology [160]. This evidence concerns the gene ALKBH5 and Parkinson disease.