Nonetheless, in DN, EV proteome can also serve as a reservoir of potential biomarkers of disease, as suggested by the first study on human urinary sEV proteome from DN patients, which identified a panel three proteins (alpha-1-microglobulin/bikunin precursor (AMBP), mixed-lineage leukemia protein 3 (MLL3) and voltage-dependent anion-selective channel 1 (VDAC1)) whose expression was changed in DN [119]. This evidence concerns the gene KMT2C and liver dysplastic nodule.