MAPK3 and osteopetrosis: The fact that these proteins are linked to the known pathogenesis of osteopetrosis (specifically the ERK1/2/Annexin/NaK ATPase/Calcineurin pathway) in the Ingenuity Pathway Analysis (IPA) indirectly confirms that the biological information of these protein panels is related and relevant to changes induced by OP disease treatment agents (Figure 3 and Figure 5).