Numerous studies have shown that the cGAS-STING signaling pathway, one of the pattern recognition receptors (PRRs) of innate immunity, plays a pivotal role in the prevention and treatment of metabolic diseases, and this pathway may be a new target to combat metabolic diseases such as obesity and T2DM [2]. The gene discussed is STING1; the disease is obesity due to melanocortin 4 receptor deficiency.