Thus, in the present study, we aimed to evaluate, for the first time, the longitudinal expression of the NLRP3 inflammasome and related ILs (1α, 1β, 18, 33 and 37) in PD individuals that did or did not develop T2DM, and we found that glycemic control favorably altered the NLRP3 inflammasome complex (NLRP3, IL-1α and IL-33 levels). This evidence concerns the gene NLRP3 and type 2 diabetes mellitus.