It is hypothesized that the status of the NLRP3 inflammasome and related interleukins (1α, 1β, 18, 33 and 37) can be identified as surrogate biomarkers that allow for the prediction of PD individuals who will progress to T2DM and/or revert to a normoglycemic status. Here, NLRP3 is linked to type 2 diabetes mellitus.