Here, we show, for the first time, that Ptgfr expression is significantly increased in TAC vs. SHAM rat hearts, a GPCR that is primarily expressed by cardiac fibroblast and cardiomyocytes, and that the inhibition of Ptgfr by the small molecule AL 8810 prevents Ang-II-induced cardiomyocyte hypertrophy in vitro. This evidence concerns the gene AGT and persistent truncus arteriosus.