However, to the best of our knowledge, Ptgfr was demonstrated to be involved in atherosclerosis and blood pressure regulation [18,19], bleomycin-induced pulmonary fibrosis [20], as well as in the collagen synthesis of cardiac fibroblasts [21], but Ptgfr has never been investigated in the pathogenesis of systolic dysfunction to date. Here, PTGFR is linked to atherosclerosis.