This DRD2 variant decreases D2R expression in human renal proximal tubule cells [175] and the Taq1A2A2 genotype is associated with hypertension with decreased iliac and tricep skinfold thickness [169,187,188,189,190] By contrast, the TaqA1 allele frequency is increased in individuals with type 2 diabetes [191]. This evidence concerns the gene DRD2 and type 2 diabetes mellitus.