DRD2 and hypertensive disorder: Renal rescue of Drd2 function in these mice using retrograde ureteral infusion of adeno-associated virus (AAV9) vectors, carrying DRD2 cDNA, reduced the expression of pro-inflammatory factors and kidney injury, preserved renal function, and normalized systolic and diastolic blood pressures, thus demonstrating that the primary D2R effect is anti-inflammatory and antifibrotic, and renal damage induced by defective D2R function is the cause and not the result of hypertension [159,160].