SMARCA4 and amyotrophic lateral sclerosis: Nonetheless, it was interesting to observe that the depletion of nBAF subunits and the delayed attrition upon Brg1 co-expression were not unique to TDP-43; indeed, they were observed also for ALS-linked FUS mutants, and loss of nBAF subunits has also been reported to occur in spinal motor neurons of familial ALS (fALS) and sporadic ALS (sALS) patients with C9orf72 GC expansion (C9ALS) or sALS without mutations in common ALS-linked genes [57].