Interestingly, post-mortem brain tissues from ALS patients TDP-43-negative nuclei in which L1 decondensation has been reported were also shown to specifically display a reduced autoregulation, indicated by decreased splicing of the cryptic 3′UTR intron with respect to TDP-43-positive nuclei within the same brain region. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.