RNA-IP and RNA pull-down assays in human neuroblastoma SH-SY5Y and embryonic kidney HEK293T cells demonstrated that TDP-43, in complex with FMRP (fragile X mental retardation protein) and STAU1 (Staufen) proteins, specifically binds to the 3′-UTR of SIRT1 mRNA and positively regulates its stability and hence its protein production [102] (Figure 2D). Here, TARDBP is linked to neuroblastoma.