The colocalization or interaction between TDP-43 and PRC2 or PRC1 have not been reported yet, but PRC2 target genes were recently found derepressed in post-mortem brain samples from ALS/FTD patients with C9orf72 (C9) repeat expansions, and the PCR2 HMT subunit EZH2 was found largely insoluble [88]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.