Thus, several thousands of DMRs were identified in the ALS sub-group as compared to control, yet a fraction (123 hypermethylated, 179 hypomethylated DMRs) was common to all subgroups, and partially overlapped with the TARDBP mutations (G298S and N390D)-holding subgroup [74]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.