In their recent work on the post-mortem brain of FTD patients, Liu and colleagues integrated their transcriptome analyses with ATAC-seq to examine changes in chromatin accessibility in TDP-43-negative nuclei relative to TDP-positive nuclei from the same samples for seven FTD and FTD–ALS brains [65]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.