Other studies have demonstrated that changes in USP7 protein expression can modulate colon carcinoma growth and sensitivity to apoptosis in vivo via the stabilization of p53, due to USP7-mediated deubiquitination of p53 proteins [26,27,28], leading to high levels of p53 and restoring the sensitivity to apoptosis by irradiation [29]. Here, USP7 is linked to colon carcinoma.