While the relationship between USP7 and EZH2 and its significance in NB pathogenesis have not yet been established, our results have shown direct correlations between USP7 downregulation induced by inhibition of its deubiquitinase activity via Almac4 or by USP7 depletion and EZH2 and N-Myc ubiquitination and protein degradation. This evidence concerns the gene USP7 and neuroblastoma.