Finally, in a clinical setting of chronic liver diseases, a study reported that CD4+ T cell-derived sEV isolated from the blood of active chronic hepatitis C (CHC) patients is more abundant than those obtained from non-alcoholic fat liver (NAFL) disease or from nonalcoholic steatohepatitis (NASH), suggesting the use of sEV quantity to distinguish between these diseases’ activity [86]. This evidence concerns the gene CD4 and metabolic dysfunction-associated steatohepatitis.