In the same context, a recent article published suggested that sEV derived from macrophages transfected with the lysosomal enzyme tripeptidyl peptidase-1 (TPP1), an enzyme used as a target for treating Batten disease (BD, a pathology that affects the nervous system in children), could be used as an alternative cure for this pathology. Here, TPP1 is linked to juvenile neuronal ceroid lipofuscinosis.