TAPBPL-Ig also significantly decreased the clinical scores of arthritis in CIA mice with an average clinical score of 12 in the control Ig group, a score of 9 in the 25 μg TAPBPL-Ig-treated group, and a score of 6 in 50 μg TAPBPL-Ig-treated group on day 58 (Figure 1B). This evidence concerns the gene TAPBPL and arthritic joint disease.