GPT and cholestasis: As for canine serum biochemical parameters, the quantified plasma renal dysfunction biomarkers (such as symmetrical dimethylarginine, creatinine, urea nitrogen, total protein, albumins), hepatocellular necrosis biomarkers (such as aspartate transaminase (AST), alanine transaminase (ALT), cholestasis, alkaline phosphatase (ALP), glutamyl transferase (GMT)), and inflammation biomarkers (such as C-reactive protein) of the CCD group were significantly increased compared with the ND group (CCD vs. ND, p < 0.01–0.05).