THBS1 and cancer: As depicted in Figure 8, and as compared with ECs incubated with control media, CM from CCs and/or from TNBC monocultures upregulated the gene expression of these angioregulatory factors, except for THBS1, which was significantly downregulated, corroborating the promotion of a proangiogenic profile in ECs exposed to CM from cancer cells (Figure 8).