The epigenetic suppression of SOCS in HCC can be countered by inhibiting DNA methyltransferase (DNMT) using Decitabine (5-aza-2′-deoxycytidine or 5-Aza-CdR) and inhibiting histone deacetylase (HDAC) using Vorinostat (suberoylanilide hydroxamic acid or SAHA). The gene discussed is CISH; the disease is hepatocellular carcinoma.