Among the numerous inflammatory cytokines associated with the activation of the JAK/STAT signaling in HCC, this review focuses on IL-6 family cytokines, IL-10 family cytokines, IL-23 as a member of IL-12 family cytokines, and IL-17, which play critical roles in the pathogenesis of HCC (Figure 4). The gene discussed is IL6; the disease is hepatocellular carcinoma.