STAT3 and hepatocellular carcinoma: Genes that are transcriptionally activated by STAT3 in HCC include CCND1 (encoding Cyclin D1), BCL2, BIRC5 (encoding Survivin), HIF-1α, VEGF, CD133 (encoding Prominin-1), NANOG, IL-10, TWIST, MMP9, etc. [92,93,94,95,96,97,98,99].