Anti-Zbtb20 immunostaining has a high affinity towards tumors of glandular origin, which proves extremely valuable in everyday pathology practice in highly differentiated adenocarcinomas (G1), where the differential diagnosis between a benign and malignant tumor is often difficult to place, especially on small biopsies and poorly differentiated ones (G3), where the histogenic group of the tumor can often be challenging to define [68,69]. Here, ZBTB20 is linked to neoplasm.