LCN2 and Polydipsia: Furthermore, CSF intervention relieved polydipsia, polyuria, and albuminuria in DN mice and alleviated the injury of glomerular as well as tubular via reducing glomerular tuft area (GTA), glomerular tuft volume (GTV), glomerular basement membrane (GBM), N-acetyl-β-d-glucosamine-dase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), and TGF-β1.