Taken together, these findings elucidated that the protective effects of CSF on ketoacidosis, angiopathy, myocardial infarction, and retinopathy triggered by DM might be partially ascribed to its capacity to modulate MAPK signal as well as the cross-talks covering JNK/Nrf-2, P2X7R/p38, and ERK1/2-NF-κB. The gene discussed is MAPK3; the disease is diabetes mellitus.