Likewise, Zhao et al. observed that CSF alleviated the disorder appearance of new vessels, the thinning of retinas, and the increase in blood glucose in STZ-induced diabetic retinopathy (DR) rats via up-regulating the expressions of p-AKT, p-PI3K, AKT1, and CTNNB1 [57]. The gene discussed is AKT1; the disease is diabetic retinopathy.