KDM6A and adrenal cortex carcinoma: Mutations in the epigenetic modifier genes CREPPB, KANSL1 are involved in histone acetyltransferase activity, KDM6A involved in histone demethylase activity, BCOR involved in histone deacetylase activity and ARID1B in the SWJ/SNF chromatin remodelling complexes are found in approximately 50% of ACC.