RPE65 and Leber congenital amaurosis: OCT images were observed in a study conducted by Reiko et al. An animal model of LCA and RP of mutated RPE65 mice, compared with histological and electron microscopy results and electroretinography (ERG) features [73] showed that the layer of the inner and outer segments of the photoreceptors was represented by a diffuse hyper-reflective zone that resembled that found by [74] in humans.