RPE65 and Leber congenital amaurosis: The same RPE65 gene is also involved in the development of the following retinal dystrophies: Leber Congenital Amaurosis (LCA), Retinitis Pigmentosa (RP), Bardet Biedel (BBS), Congenital Stationary Night Blindness (CSNB) and Usher Syndrome (USH).