The expression of MAF in antitumor CD8+ T cells contributes to their polarization toward a depleted phenotype, and TGF-β and IL-6 are able to induce MAF expression in CD8+ T cells in vitro and in vivo, while tumor-specific CD8+ T cells lacking MAF tend to eliminate melanoma cells [27,28]. The gene discussed is TGFB1; the disease is melanoma.