It has been demonstrated that M1 macrophages expressed high levels of CD86, MHC II and B7 and mediated anti-tumor effects by secreting high-level cytokines (such as IL-12, IL-23, IL-1 and IL-6) and chemokines (MCP-1, CCL3, CXCL9, CXCL10, etc.)[7]. This evidence concerns the gene CCL2 and neoplasm.