Activation of SIRT6 also leads to a decrease in the expression of ERRγ (orphan nuclear receptor estrogen-related receptor γ), which leads to a reduced Cyp7a1 (cholesterol 7α-hydroxylase) transcription and, consequently, to the protection of a liver against cholestasis and fibrosis, resulting from the increased production of bile acids or their disturbed outflow. Here, CYP7A1 is linked to cholestasis.