LINC01605 was found to be downregulated upon mut_TP53 silencing in MDA-MB-231 breast cancer and OVCAR8 ovarian cancer cells, and we confirmed that mut_p53 directly regulates LINC01605 expression by binding to an enhancer region located 20 kb upstream of the LINC01605 first exon. Here, TP53 is linked to ovarian cancer.