When the differentially expressed genes were ranked based on FDR, 11 genes were found in the top-25 genes of both the 231MXRA8KO-O vs. 231MXRA8Con tumors and the 231MXRA8KO-V vs. 231MXRA8Con tumors, and these genes are shown in the heatmap in Figure 4D. In particular, ADAMTS1, TIE1, and BMP2 were in the top-10 differentially expressed genes in both 231MXRA8KO-O vs. 231MXRA8Con tumor and 231MXRA8KO-V vs. 231MXRA8Con tumor comparisons. The gene discussed is BMP2; the disease is neoplasm.