This approach was used in a paper from this year that shows significant upregulation of SOCS3, ITGAL, NFIC, NCOR2, and PGK1 mRNA (qRT-PCR) in peripheral blood mononuclear cells from pulmonary arterial hypertension (PAH) patients compared to healthy controls (p ≤ 0.05) [39]. The gene discussed is NFIC; the disease is pulmonary arterial hypertension.