On the other hand, Cdkn2c (cyclin-dependent kinase inhibitor 2c) was upregulated in the UON at the three day crush time point, and Cdkn3 (cyclin-dependent kinase inhibitor 3), which prevents the activation of Cdk2, was also increased in early glaucoma in this same region. The gene discussed is CDKN3; the disease is glaucoma.