MON had a more consistently higher expression of some A2 astrocyte markers (e.g., Ptgs2, Slc10a6, B3gnt5) in the early crush and glaucoma time points that shifted to an upregulation of A1-specific (detrimental) markers (e.g., Serping1, C3, Fbln5) after two weeks; however, neither an A1 nor A2 phenotype dominated in our time course of ON injury samples (Figure 5D). This evidence concerns the gene SERPING1 and glaucoma.