The localization of p-PDHA1 and PKM2 in HCC, HB, and ChC tissues were significantly higher in the nucleus compared to the control non-neoplastic hepatocyte tissues around tumour tissues, suggesting that nuclear localization of p-PDHA1 and PKM2 may be a characteristic feature of liver cancer tissue (Figure 5D–F). Here, PDHA1 is linked to hepatocellular carcinoma.