Pathological tau is characterized by detergent insolubility [29,30,31], decreased mobility by SDS-PAGE due to phosphorylation events [9,32], reduced ability to promote microtubule polymerization [32,33], and conformational changes that manifest as filamentous aggregates found in neurons and glial cells in the brains of individuals with neuropathological diagnosis of a tauopathy [34,35,36,37]. This evidence concerns the gene MAPT and tauopathy.