Inhibitors of the IL-6/JAK/STAT3 signaling cascade, such as siltuximab (anti-IL6), P6 (pan-JAK inhibitor), galiellalactone (anti-STAT3) and LLL12 (which blocks STAT3 phosphorylation), have also been studied in PC [176,177]. This evidence concerns the gene IL6 and pachyonychia congenita.