Therefore, in this study, we were interested in determining whether the use of kinetic parameters derived from direct Patlak reconstructions of [68Ga]Ga-PSMA-11 PET/CT are superior to the standard static parameters, to standardized uptake values (SUV), and in predicting the histological grading of malignancy of the primary tumor of patients with PCa. This evidence concerns the gene FOLH1 and posterior cortical atrophy.