Therefore, iPSA and PSMA-PET parameters might be less related to the degree of pathological aggressiveness of the prostate tumor. This was also seen in another study of 31 patients with BCR-PCa [26] and more recently in a study by Bogdanovic et al. that showed no or only a weak correlation between dynamic and static parameters derived from PSMA (68Ga-PSMA-11, 18F-PSMA-1007, and 18F-rhPSMA7) PET/MRI images and PSA levels and GS grading in 100 patients with primary PCa [27]. This evidence concerns the gene KLK3 and posterior cortical atrophy.