Moreover, R-spondin-2 and olfactory receptor 52R1 were also detected in 80% of T2 tumor samples, but R-spondin-2 was also found in 50% of the samples of patients with T3 + T4 tumors, and olfactory receptor 52R1 was found in 25% of the samples of patients in this group (Table S5). Here, RSPO2 is linked to neoplasm.