Among proteins identified only in serum exosomes of NSCLC patients, HUWE1-associated protein modifying stress responses, mitochondrial adenylate kinase 2, cytochrome c oxidase assembly protein COX11, mitochondrial homeobox protein Nkx-2.8, insulin-like growth factor-binding protein 1, kallikrein-8, neuroblastoma suppressor of tumorigenicity 1, potassium channel tetramerization domain containing 6, and zinc finger FYVE domain-containing protein 21 were detected only in patients with diagnosed AC subtypes of NSCLC (Table S4). The gene discussed is HUWE1; the disease is non-small cell lung carcinoma.