NERD is considered as a subset of the late-onset eosinophilic asthma phenotype—frequently associated with chronic rhinosinusitis with nasal polyps (CRSwNP)—presenting with rapid respiratory exacerbations immediately triggered after the intake of aspirin or other NSAID drugs that inhibit the cyclooxygenase-1 isoenzyme (COX-1). The gene discussed is PTGS1; the disease is chronic rhinosinusitis with nasal polyps.