PTGS1 and chronic rhinosinusitis: NERD is considered as a subset of the late-onset eosinophilic asthma phenotype—frequently associated with chronic rhinosinusitis with nasal polyps (CRSwNP)—presenting with rapid respiratory exacerbations immediately triggered after the intake of aspirin or other NSAID drugs that inhibit the cyclooxygenase-1 isoenzyme (COX-1).