Thus, the definition of the Th2-high asthma phenotype was initially based on atopic predisposition in combination with any of the following surrogate biomarkers for Th2 immune activation: serum immunoglobulin E (IgE) ≥ 100 IU/mL, blood eosinophil count ≥ 300/μL, and exhaled nitric oxide fraction (FENO) ≥ 30 ppb [13]. The gene discussed is IGHE; the disease is asthma.