Moreover, a whole-genome sequencing association study of asthma severity in Europeans evidenced eight genome-wide significant loci previously reported as associated with asthma (IL1RL2, TSLP, HLA-DQA1, BACH2, C11orf30, RAD51B, and GSDMB) and lung function (THSD4) [94]. This evidence concerns the gene HLA-DQA1 and asthma.