Additional evidence is also needed to confirm whether ALDH1A1 expression drives tumor growth, and/or whether recurrent AML tumors have larger populations of cancer stem cells; though, we do see an association between ALDH1A1 expression and stemness (Figure 3) based on a previously published AML stemness signature, where stemness was functionally defined [43]. This evidence concerns the gene ALDH1A1 and acute myeloid leukemia.