LDHA and acute erythroblastic leukemia: For AML class M6, a rare disease named acute erythroblastic leukemia that involves either undifferentiated or proerythroblast cells with no direct connection with ALDH exists in the literature; however, this connection is plausible because (a) during the course of erythroid differentiation, ALDH loses intensity, and (b) all reported erythroid cell lines that have been immortalized to date derive from the proerythroblast stage, with “evasion of oxidative stress-induced senescence” being the most represented pathway alteration [53].