While studies on NR3C1 methylation focus on psychopathologies, with scarce studies on MetS or its components, several polymorphisms have already been associated with them, with emphasis on the single-nucleotide polymorphisms (SNPs) rs56149945 (p.N363S), rs41423247 (BclI), rs6189/6190 (ER22/23EK), rs10052957 (TthIIII), and rs6198 (GR-9β), which seem to modulate the sensitivity to glucocorticoids [3,26]. Here, NR3C1 is linked to metabolic syndrome.