GLA and Nager acrofacial dysostosis: Anderson–Fabry disease (AFD, OMIM #301500) is a rare, X-linked lysosomal storage disorder that arises from mutations in the GLA gene (Gene Entrez: 2717; NCBI reference sequence: NM_000169.3; OMIM #300644; Locus Reference Genomic record LRG_672), which is responsible for encoding the enzyme α-galactosidase A (α-Gal A, EC 3.2.1.22; Uniprot P06280).