Studies of allelic variants of PCSK1 rs6235 G allele, TMEM18 rs6548238 C allele, GPX5 rs445870 G allele, ZPR1 rs964184 G allele, ZBTB16 rs7106340 T allele, and PPARG1 rs3856806 T allele are limited or absent in adults from northwestern Mexico, and their association with metabolic diseases is not well known. Here, TMEM18 is linked to metabolic disease.