PCSK1 and Other metabolic disease: Of the six SNPs studied, two showed individual associations with metabolic diseases; one of them was the G rs6235 allele of PCSK1, which had an allele frequency of 39.3% in obese individuals versus 29.1% in individuals of normal weight and was significantly associated with obesity, increasing 1.54 times the probability of suffering from this pathology (95% CI: 1.22–1.92; p: 1.0 × 10−4) (Table 6).