In contrast to ADPKD, where genes encode proteins that localize to the primary cilium, the gene products implicated in ADPLD (PRKCSH, SEC63, SEC61A, SEC61B, GANAB, ALG8, and ALG9) are all involved in the co-translational translocation and maturation of glycoproteins in the endoplasmic reticulum [15,16,24]. This evidence concerns the gene ALG9 and autosomal dominant polycystic kidney disease.