This contrasts with the earlier truncated Immp2lTg(Tyr)979Ove mouse that suggested loss of Immp2l activity was associated with an increase in ROS production and oxidative stress phenotypes including oxidative stress in the brain causing ataxia and neurodegeneration [3,28,29,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71]. This evidence concerns the gene IMMP2L and Ataxia.