The knockout of Immp2l activity and the treatment with MitoQ each independently reduced the ratio of open-arm entries (genotype main effect: F(1,56) = 8.262, p = 0.006; treatment main effect: F(1,56) = 7.850, p = 0.007; Figure 3E), which indicates increased avoidance of the aversive area considered to reflect anxiety-relevant behaviour. This evidence concerns the gene IMMP2L and Anxiety.