Several studies have reported that the lncRNAs colorectal neoplasia differentially expressed (CRNDE), prostate cancer-associated transcript 6 (PCAT6), DLGAP1 antisense RNA 1 (DLGAP1-AS1), and HOXA11 antisense (HOXA11-AS) are highly expressed in HCC, and their overexpression has been linked to HCC invasion and/or metastasis [20,21,22,23]. The gene discussed is CRNDE; the disease is hepatocellular carcinoma.