Most models of susceptibility to AMD, its progression from the early to the late stages, and the determination of specific subtypes (CNV, GA) or treatment outcomes [30] involve recurrent gene loci, including CFH, ARMS2/HTRA1, C2, C3, and CFB, which is consistent with the GWAS results for AMD and related traits. The gene discussed is C3; the disease is age-related macular degeneration.