In our current gut microbiome analysis, we included a non-mutant human tau (htau) mouse model that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at 3–4 months and in which tau dysregulation and neuronal loss correlate with synaptic dysfunction and cognitive decline [28]. The gene discussed is MAPT; the disease is Mental deterioration.