Additional mutated genes implicated in a subset of CMs in individual reports (e.g., CTNNB1, ACSS3, PREX2, APOB, RYR1/2, SYK, NOTCH3, CHEK2, KMT2A/C, ARID2, FAT4, RB1, APC, as well as some MAPK/MAP2K/MAP3K genes, PIK3CA/B/G genes, additional RTK genes (e.g., RET and ERBB genes), and some HDAC and additional SETD genes) [27,28,30,31,32,34,77] warrant further investigation to determine their relevance to CM pathogenesis. This evidence concerns the gene PIK3CA and cutaneous mastocytosis.