PDCD4 and neoplasm: While most CNAs identified in CMs to date do not seem to have any clinical/prognostic value, recurrent deletions occurring at 10q24-26 (the region harboring the tumor suppressor genes NEURL1, SUFU, PDCD4, and C10orf90) were reported to be associated with increased tumor thickness, lymphatic invasion, and metastatic spread of CM [33].