While CM has an overall distinct genetic profile, overlapping more with that of skin and mucosal melanomas than that of uveal melanoma, mutations affecting uveal melanoma-associated genes BAP1, SF3B1, and GNAQ/11 have also been detected in CMs, albeit less frequently, including both uveal melanoma-related hotspot mutations and other mutations [27,28,29,31,38,77,78]. The gene discussed is GNAQ; the disease is uveal melanoma.