CLU and Alzheimer disease: Additionally, our CompG models showed that 25 SNP pairs mapped to the CLU locus (β coefficients ranged from −0.288 to 0.386) and 24 SNP pairs mapped to the ABCA7 locus (β coefficients ranged from −0.282 to 0.186) were associated with AD, while their comprising SNPs were not associated with AD in the single SNP models (Table 3, Table 4, Tables S3 and S5).